Nuno Gama was born in Azeitão, and graduated in Fashion Design by Citex, in Porto. He began his collaboration with the textile industry very early on and began selling his collections in selected stores in Lisbon and Porto. In 1993, he launched his brand, which has since been presented at ModaLisboa - Lisboa Fashion Week.

In 1999, he began his work as coordinator of the Maconde Group's Man collection. In 2005, he launched the "Gama de Casa" at ModaLisboa and started his collaboration with Pinho Vieira brand. In the following year, he returned with Gavesa Lda and continued to develop the "Gama de Joalharia" and "Gama de casa" lines.

In 2008, he inaugurated his Store & Atelier, in Porto. In February 2012 he moved his company to Lisbon and opened his shop & studio in Príncipe Real.

In March 2016, in the context of ModaLisboa, he presented the autobiographical film "50's Nuno Gama" at the CCB. In September he presented the fall / winter collection 16/17 at the his gala celebrating his 50th & 30th career, at Casino Estoril, in favour of the Portuguese Red Cross. In November, he launched his ninth line of sport and is named by the International Academy of Arts and Sciences of NY in the category of best show of the year.

In 2017, he presented the collection Summer 18 in Showcase ModaPortugal — held at Galerie Perrotin, Paris, during the Men's Fashion Week — and launched, along with BMW Portugal, Mini Gama Gentleman and a 2nd Sport version, nicknamed Quinas.

In December 2018, he opened the Maison Nuno Gama in Chiado, Lisbon. In June 2021, he left Chiado and opened a new space in Praça da Ilha do Faial.

Along with the development of his collections, Nuno Gama often collaborates in the creation of wardrobes for dance and theatre shows and develops uniforms for various entities.